Zepbound: What You Should Know About This Weight-Loss Medication

Zepbound™ (tirzepatide) is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for chronic weight management in adults. It’s part of a new generation of injectable weight-loss treatments that support people who have struggled to lose weight through diet and exercise alone.

Here’s what you need to know about Zepbound — including how it works, who may benefit from it, potential side effects and other important considerations.

WHAT IS ZEPBOUND AND HOW DOES IT WORK?

Zepbound is an injectable medication that activates two receptors in the body called GIP and GLP-1. These hormones are involved in regulating appetite, insulin response and digestion. By mimicking their action, Zepbound can:

• Improve blood sugar regulation.
• Slow down how quickly food leaves the stomach.
• Help people feel full longer after eating.

When used alongside a healthy diet and regular physical activity, this combination may support weight loss over time. Zepbound is administered once weekly and comes in three dosage strengths: 5 mg, 10 mg and 15 mg. The exact dose is determined by your physician based on your individual health needs and response to treatment.

It’s worth noting that tirzepatide is also used under the name Mounjaro® to treat type 2 diabetes. Zepbound is specifically approved for weight management in eligible patients.

WHO IS A CANDIDATE FOR ZEPBOUND?

Zepbound is FDA-approved for adults 18 and older who are either:

• Living with obesity (defined as a body mass index [BMI] of 30 or higher).
• Overweight (BMI of 27 or higher) and have at least one weight-related health condition, such as high blood pressure, type 2 diabetes or high cholesterol.

BMI is a screening tool and may not reflect overall health for every individual. That’s why it’s important to have a conversation with your doctor, who can evaluate your full medical history and current health goals to determine if Zepbound is appropriate for you.

WHAT ARE THE COMMON SIDE EFFECTS OF ZEPBOUND?

Like most prescription medications, Zepbound may cause side effects. The most commonly reported include:

• Nausea or vomiting
• Diarrhea or constipation
• Abdominal pain or indigestion
• Fatigue
• Reactions at the injection site
• Hair loss
• Heartburn
• Belching
• Mild allergic reactions

While these side effects are typically not severe, they can be bothersome. Be sure to let your provider know about any that persist or interfere with your daily life.

ARE THERE SERIOUS RISKS ASSOCIATED WITH ZEPBOUND?

Although rare, Zepbound may lead to more serious side effects, including:

• Severe stomach issues
• Dehydration and related kidney problems
• Gallbladder complications
• Pancreatitis (inflammation of the pancreas)
• Significant allergic reactions (e.g., swelling, trouble breathing, rash)
• Low blood sugar, particularly in people with diabetes
• Changes in vision
• Thyroid tumors, including a rare type of cancer
• Mental health changes, including depression or suicidal thoughts

If you experience symptoms such as intense stomach pain, yellowing of the skin or eyes, trouble swallowing, or unusual changes in mood, contact your doctor right away.

OTHER QUESTIONS PATIENTS COMMONLY ASK

Do I Need a Prescription for Zepbound?

Yes. Zepbound must be prescribed by a licensed healthcare provider.

How Long Do I Have to Take It?

Your doctor will discuss a treatment plan with you based on your progress, overall health, and how well you tolerate the medication.

What If I Can’t Afford It?

Ask your doctor about possible assistance programs or alternatives. There may be resources available to help with the cost of weight-loss medications.

TALK WITH YOUR BAPTIST HEALTH DOCTOR

Weight loss is a personal journey, and for some, medications like Zepbound may be part of that process. If you’ve made healthy lifestyle changes but still struggle to lose weight, your doctor can help you explore safe, effective options.

If you don’t currently have a primary care provider, you can use our online directory to find one near you.

Next Steps and Useful Resources

Learn More About Weight Management at Baptist Health
Zepbound vs. Ozempic: What Are the Differences?
Zepbound vs. Wegovy: How Do They Compare?
Risks of Taking Ozempic for Weight Loss
What Is Ozempic Face?